Maeso R, Navarro-Cid J, Rodrigo E, Ruilope L M, Lahera V, Cachofeiro V
Department of Physiology, School of Medicine, Universidad Complutense, Madrid, Spain.
Am J Hypertens. 1999 Nov;12(11 Pt 1):1105-8. doi: 10.1016/s0895-7061(99)00086-2.
We evaluated the effects of treatment for 12 weeks with 10 mg/kg/day of either losartan or doxazosin on vascular function in senescent spontaneous hypertensive rats (SHR). Both doxazosin and losartan reduced blood pressure, although the former was more effective. In contrast, both drugs reduced relative aortic weight and increased plasma nitrates to a similar extent. Losartan, but not doxazosin, increased the magnitude of the response to acetylcholine (10(-9) to 10(-5) mol/L). Both treatments increased relaxations to sodium nitroprusside (10(-10) to 10(-6) mol/L). These data show that losartan may possess advantages over doxazosin in improving vascular function in senescent SHR. This report emphasizes the importance of angiotensin II in vascular function alterations induced by aging in SHR.
我们评估了给予老年自发性高血压大鼠（SHR）10mg/kg/天的氯沙坦或多沙唑嗪治疗12周对血管功能的影响。多沙唑嗪和氯沙坦均可降低血压，尽管前者效果更佳。相比之下，两种药物降低主动脉相对重量和增加血浆硝酸盐的程度相似。氯沙坦可增加对乙酰胆碱（10⁻⁹至10⁻⁵mol/L）的反应幅度，而多沙唑嗪则无此作用。两种治疗均增加了对硝普钠（10⁻¹⁰至10⁻⁶mol/L）的舒张反应。这些数据表明，在改善老年SHR的血管功能方面，氯沙坦可能优于多沙唑嗪。本报告强调了血管紧张素II在SHR衰老诱导的血管功能改变中的重要性。
