Andrews L S, Sonawane B R, Yaffe S J
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):319-30.
Benzo(a)pyrene hydroxylase activity was found in the bone marrow of control and 3MC-induced New Zealand white rabbits. This activity was localized in the microsomal fraction, was NADPH dependent and CO sensitive. The reaction was inhibited by 7,8-benzoflavone indicating that it was mediated by the 3MC-inducible form of cytochrome P-450. BP hydroxylase activity in rabbit bone marrow was located primarily in white cells, and was considerably higher than that previously reported for cultured human lymphocytes and monocytes. A possible role for the bone marrow mixed-function oxygenase in the production of hemopoietic toxicity is considered.
在对照及3-甲基胆蒽诱导的新西兰白兔的骨髓中发现了苯并(a)芘羟化酶活性。该活性定位于微粒体部分，依赖于NADPH且对CO敏感。该反应被7,8-苯并黄酮抑制，表明它是由细胞色素P-450的3-甲基胆蒽诱导型介导的。兔骨髓中的BP羟化酶活性主要位于白细胞中，且明显高于先前报道的培养人淋巴细胞和单核细胞中的活性。考虑了骨髓混合功能氧化酶在产生造血毒性中的可能作用。
