Stroud R M, Walter P
S-960 Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco CA 94143-0448, USA.
Curr Opin Struct Biol. 1999 Dec;9(6):754-9. doi: 10.1016/s0959-440x(99)00040-8.
Intracellular traffic is often controlled not by highways, but by handshakes and partner introductions within a cellular network. Recently determined structures suggest how signal sequences are recognized and how the GTP affinities of the signal recognition particle and its receptor are coupled to the targeting of ribosomes to translocational membrane pores. The structure of signal peptidase suggests how it releases functional proteins.
细胞内运输通常不是由“高速公路”控制，而是由细胞网络内的“握手”和伙伴介绍来控制。最近确定的结构表明信号序列是如何被识别的，以及信号识别颗粒及其受体的GTP亲和力是如何与核糖体靶向转位膜孔相耦合的。信号肽酶的结构表明了它是如何释放功能蛋白的。
