Moor R M, Allen W R, Hamilton D W
J Reprod Fertil Suppl. 1975 Oct(23):391-5.
Biochemical and morphological studies were carried out to determine the origin and histogenesis of endometrial cups in mares. A wide range of fetal and maternal tissues were cultured in vitro and their ability to secrete gonadotrophin (PMSG) was monitored. High levels of PMSG were produced in culture only by cells from the restricted area of the equine trophoblast known as the chorionic girdle which is an annular band of highly specialized cells at the junction of the allantois and the regressing yolk sac. The morphological appearance of girdle cells after cultivation in vitro and after allogeneic grafting to the uterus or testis was identical to that of endometrial cup cells. Firm attachment between the cells of the chorionic girdle and the adjacent endometrium occurs on Day 36. Girdle cells then rapidly invade and phagocytose the endometrial epithelium, and migrate into the endometrial glands and the uterine stroma where they differentiate into large, sessile endometrial cup cells.
开展了生化和形态学研究，以确定母马子宫内膜杯的起源和组织发生。对多种胎儿和母体组织进行了体外培养，并监测它们分泌促性腺激素（孕马血清促性腺激素，PMSG）的能力。仅来自马滋养层特定区域（称为绒毛带）的细胞在培养中产生了高水平的PMSG，绒毛带是尿囊和退化卵黄囊交界处的一圈高度特化细胞。体外培养后以及同种异体移植到子宫或睾丸后，绒毛带细胞的形态外观与子宫内膜杯细胞相同。绒毛带细胞与相邻子宫内膜在第36天牢固附着。然后，绒毛带细胞迅速侵入并吞噬子宫内膜上皮，并迁移到子宫内膜腺体和子宫基质中，在那里它们分化为大的、无柄的子宫内膜杯细胞。
