缺血性损伤对离体兔心脏中Tc-99m N-NOET心脏转运的影响。

The effect of ischemic injury on the cardiac transport of Tc-99m N-NOET in the isolated rabbit heart.

作者信息

Holly T A, Leppo J A, Gilmore M P, Reinhardt C P, Dahlberg S T

机构信息

Division of Cardiology, Northwestern University Medical School, Chicago, Ill, USA.

出版信息

J Nucl Cardiol. 1999 Nov-Dec;6(6):633-40. doi: 10.1016/s1071-3581(99)90101-0.

DOI:10.1016/s1071-3581(99)90101-0

PMID:10608591

Abstract

BACKGROUND

Bis (N-ethoxy, N-ethyl dithiocarbamato) nitrido technetium-99m (V) (TcN-NOET) is a neutral lipophilic myocardial perfusion agent. The effect of ischemic injury on the cardiac transport of TcN-NOET and thallium-201 was determined in isolated rabbit hearts.

METHODS AND RESULTS

The multiple indicator dilution method was used to determine the maximum (Emax) and net extraction (Enet, at 5 minutes) of TcN-NOET and TI-201 at control and after 10 minutes (n = 4) or 45 minutes (n = 4) of no-flow ischemia. After 10 minutes of ischemia the mean Emax for T1-201 was unchanged, 0.86 +/- 0.03 vs 0.85 +/- 0.02, whereas TI-201 Enet showed a small decrease from 0.46 +/- 0.03 to 0.40 +/- 0.03, P < .001. Forty-five minutes of ischemia mildly reduced Emax for TI-201 (0.87 +/- 0.04 to 0.74 +/- 0.04, P < .001) and severely reduced Enet (0.46 +/-0.03 vs 0.16 +/- 0.04, P < .001). Neither Emax nor Enet for TcN-NOET was significantly affected by 10 minutes of ischemia (0.54 +/- 0.04 vs 0.58 +/- 0.03 and 0.24 +/- 0.04 vs 0.26 +/- 0.04, respectively). However, severe ischemic injury caused significant reductions versus control in both Emax (0.59 +/- 0.06 vs 0.42 +/- 0.05, P < .001) and Enet (0.27 +/- 0.03 vs 0.18 +/- 0.05, P < .01).

CONCLUSIONS

TcN-NOET is a new myocardial perfusion agent with moderate myocardial extraction. Although less sensitive than TI-201 to mild ischemic injury, TcN-NOET extraction and retention are decreased by severe ischemic injury, making uptake of TcN-NOET a possible marker of myocardial viability.

摘要

背景

双（N - 乙氧基，N - 乙基二硫代氨基甲酰基）氮-99m（V）锝（TcN - NOET）是一种中性亲脂性心肌灌注剂。在离体兔心脏中测定了缺血性损伤对TcN - NOET和铊-201心脏转运的影响。

方法与结果

采用多指示剂稀释法测定对照组以及无血流缺血10分钟（n = 4）或45分钟（n = 4）后TcN - NOET和TI - 201的最大摄取量（Emax）和净摄取率（Enet，5分钟时）。缺血10分钟后，TI - 201的平均Emax未改变，分别为0.86±0.03和0.85±0.02，而TI - 201的Enet略有下降，从0.46±0.03降至0.40±0.03，P <.001。缺血45分钟使TI - 201的Emax轻度降低（从0.87±0.04降至0.74±0.04，P <.001），Enet严重降低（从0.46±0.03降至0.16±0.04，P <.001）。缺血10分钟对TcN - NOET的Emax和Enet均无显著影响（分别为0.54±0.04和0.58±0.03，以及0.24±0.04和0.26±0.04）。然而，严重缺血性损伤导致Emax（从0.59±0.06降至0.42±0.05，P <.001）和Enet（从0.27±0.03降至0.18±0.05，P <.01）均较对照组显著降低。