使用非织造聚酯纤维过滤器治疗炎症性肠病的白细胞去除新技术。

New technique of leukocytapheresis by the use of nonwoven polyester fiber filter for inflammatory bowel disease.

作者信息

Kawamura A, Saitoh M, Yonekawa M, Horie T, Ohizumi H, Tamaki T, Kukita K, Meguro J

机构信息

Department of Surgery, Sapporo Hokuyu Hospital, Japan.

出版信息

Ther Apher. 1999 Nov;3(4):334-7. doi: 10.1046/j.1526-0968.1999.00207.x.

DOI:10.1046/j.1526-0968.1999.00207.x

PMID:10608731

Abstract

Leukocytapheresis (LCAP) is widely used for the treatment of immunological diseases. We studied a new treatment of LCAP using a nonwoven polyester fiber filter. In a basic study, 30-70% of leukocytes were removed. Also, 30-68% of the leukocyte subsets were removed. Sixteen inflammatory bowel disease (IBD) patients, mainly with ulcerative colitis (UC), were treated by this method. Their cytokine activity was normalized in the filter and in the peripheral blood. Eleven of 12 patients with UC were induced to remission. Four patients with Crohn's disease (CD) exhibited improvement. The LCAP using a nonwoven polyester fiber filter was very efficient for treating the patients with IBD. Also, it will be a very useful treatment for immunological diseases and extracorporeal immunomodulation.

摘要

白细胞去除术（LCAP）被广泛用于治疗免疫性疾病。我们研究了一种使用聚酯无纺布纤维过滤器的白细胞去除术新疗法。在一项基础研究中，30%至70%的白细胞被去除。此外，30%至68%的白细胞亚群被去除。16例炎症性肠病（IBD）患者，主要是溃疡性结肠炎（UC）患者，接受了该方法治疗。他们的细胞因子活性在过滤器和外周血中恢复正常。12例UC患者中有11例诱导缓解。4例克罗恩病（CD）患者病情改善。使用聚酯无纺布纤维过滤器的白细胞去除术对治疗IBD患者非常有效。此外，它对免疫性疾病和体外免疫调节将是一种非常有用的治疗方法。