Harris K M, Robiolio P
Minneapolis Heart Institute, MN 55407, USA.
Postgrad Med. 1999 Dec;106(7):113-4, 117-20, 125 passim. doi: 10.3810/pgm.1999.12.805.
Evaluation and treatment of valvular heart disease (table 1) are in evolution. Echocardiography is the principal diagnostic tool. In general, mitral and aortic stenotic lesions warrant surgical treatment when symptoms appear. Such intervention is also indicated in symptomatic patients with a regurgitant mitral or aortic lesion. Some patients with regurgitant lesions require surgical treatment even before the onset of symptoms, such as when left ventricular dysfunction or dilatation supervenes. Surgical treatment of valvular lesions consists of repair or replacement, except in the case of mitral stenosis, where PBMC is a reasonable alternative. In general, medical therapy has a very limited role in the treatment of valvular heart disease. Severe aortic insufficiency is an exception. In such cases, afterload reduction has proved beneficial in the long-term prognosis.
心脏瓣膜病的评估与治疗(表1)正在不断发展。超声心动图是主要的诊断工具。一般而言,二尖瓣和主动脉瓣狭窄病变在出现症状时需进行手术治疗。有症状的二尖瓣或主动脉瓣反流病变患者也需进行此类干预。一些反流病变患者甚至在症状出现前就需要手术治疗,比如出现左心室功能障碍或扩张时。瓣膜病变的手术治疗包括修复或置换,但二尖瓣狭窄除外,经皮球囊二尖瓣成形术(PBMC)是一种合理的替代方法。一般来说,药物治疗在心脏瓣膜病的治疗中作用非常有限。严重主动脉瓣关闭不全是个例外。在这种情况下,降低后负荷已被证明对长期预后有益。