Jepson T L, Ernst M E, Kelly M W
University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
J Am Pharm Assoc (Wash). 1999 Nov-Dec;39(6):822-9; quiz 880-2.
To concisely review the etiology and current treatment modalities of seasonal affective disorder (SAD).
A MEDLINE search (1966-1999) was performed using the search term "seasonal affective disorder." The search was subsequently focused to "drug therapy" with limits of human studies and English-language papers. The search term "light therapy" was combined with "seasonal affective disorder."
Articles discussing the epidemiology and treatment of SAD were independently examined by each author. Additional literature was reviewed from selected references identified by the original articles.
SAD most likely results from a deficiency in serotonin. Light therapy remains the therapeutic intervention with the most experience and success. Selective serotonin reuptake inhibitors (SSRIs) have also shown benefit in treating the disorder.
SAD is an important subtype of major depressive disorder. Clinicians should remain vigilant for signs and symptoms of the illness. Successful treatment may include light therapy or antidepressants, particularly SSRIs.
简要综述季节性情感障碍（SAD）的病因及当前治疗方式。
使用检索词“季节性情感障碍”进行了MEDLINE检索（1966 - 1999年）。随后检索聚焦于“药物治疗”，限定为人体研究及英文论文。检索词“光疗”与“季节性情感障碍”相结合。
每位作者独立审查讨论SAD流行病学及治疗的文章。从原始文章确定的选定参考文献中查阅了其他文献。
SAD很可能由血清素缺乏所致。光疗仍是经验最丰富且最成功的治疗干预措施。选择性5-羟色胺再摄取抑制剂（SSRIs）在治疗该疾病方面也已显示出疗效。
SAD是重度抑郁症的一种重要亚型。临床医生应警惕该疾病的体征和症状。成功的治疗可能包括光疗或抗抑郁药，尤其是SSRIs。
