（-）-表没食子儿茶素、（-）-表儿茶素、（+）-儿茶素和（-）-表没食子儿茶素没食子酸酯与各种金属离子的DNA切割活性。

DNA cleavage activities of (-)-epigallocatechin, (-)-epicatechin, (+)-catechin, and (-)-epigallocatechin gallate with various kinds of metal ions.

作者信息

Hayakawa F, Kimura T, Hoshino N, Ando T

机构信息

Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Japan.

出版信息

Biosci Biotechnol Biochem. 1999 Sep;63(9):1654-6. doi: 10.1271/bbb.63.1654.

DOI:10.1271/bbb.63.1654

PMID:10610127

Abstract

The DNA cleavage activities of (+)-catechin (C), (-)-epicatechin (EC), (-)-epigallocatechin (EGC), and (-)-epigallocatechin gallate (EGCg) were examined with 16 different metal ions. Cu(2+) with all the catechins facilitated DNA cleavage, while Ag+ with EGC and EC showed a strong repressive effect. The other metal ions examined showed little effect.

摘要

用16种不同的金属离子检测了（+）-儿茶素（C）、（-）-表儿茶素（EC）、（-）-表没食子儿茶素（EGC）和（-）-表没食子儿茶素没食子酸酯（EGCg）的DNA切割活性。所有儿茶素与铜离子（Cu(2+)）协同促进DNA切割，而银离子（Ag+）与EGC和EC则表现出强烈的抑制作用。所检测的其他金属离子几乎没有影响。