使用羊源地高辛特异性免疫球蛋白G Fab片段治疗患有心脏病的犬的严重慢性地高辛中毒。

Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments.

作者信息

Ward D M, Forrester S D, DeFrancesco T C, Troy G C

机构信息

Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442, USA.

出版信息

J Am Vet Med Assoc. 1999 Dec 15;215(12):1808-12, 1806.

PMID:10613212

Abstract

Severe digoxin toxicosis in a 13-year-old mixed-breed dog with dilated cardiomyopathy was successfully treated with i.v. administration of ovine digoxin-specific IgG Fab fragments. Management of this dog following treatment with Fab fragments was complicated by hypomagnesemia and loss of the positive inotropic effect of digoxin.

摘要

一只患有扩张型心肌病的13岁混血犬发生严重地高辛中毒，通过静脉注射羊地高辛特异性IgG Fab片段成功治愈。用Fab片段治疗后，这只犬的管理因低镁血症和地高辛正性肌力作用丧失而变得复杂。