Farczádi E, Szántó J, Kaszás I, Benyó I, Bodnár Z, Szlobodnyik J, Szende B
Oncology Department, St Margit Hospital, Budapest, Hungary.
Neoplasma. 1999;46(4):219-23.
Fifteen patients with rectal adenocarcinoma were endoscopically biopsied and given short-term [5 fluorouracil (5FU) (600 mg/m2) and Ca-Folinate (60 mg/m2) for two days] cytostatic therapy. Seven days later the tumor was resected or a second biopsy was performed. Apoptotic and mitotic indices were determined in the tumor tissue before and after the short-term chemotherapy. The patients were treated thereafter with long-term, intermittent 5 FU administration and followed up clinically for 4-13 months. Three patients showed progression of the disease, twelve improved or showed no tumor progression. An increase of the apoptotic index and decrease of the mitotic index after the short-term cytostatic treatment were seen in the tumor tissue of responder cases. Non-responders showed increase or no change in mitotic activity, and decrease or no change in apoptotic activity. These findings suggest that apoptotic and mitotic response to short-term cytostatic therapy may be additional predictive factor in rectal adenocarcinoma.
对15例直肠腺癌患者进行了内镜活检，并给予短期（5氟尿嘧啶（5FU）（600mg/m²）和亚叶酸钙（60mg/m²），持续两天）细胞抑制治疗。7天后切除肿瘤或进行第二次活检。在短期化疗前后测定肿瘤组织中的凋亡指数和有丝分裂指数。此后，患者接受长期、间歇性5FU给药，并进行了4至13个月的临床随访。3例患者疾病进展，12例病情改善或无肿瘤进展。在有反应的病例的肿瘤组织中，短期细胞抑制治疗后凋亡指数增加，有丝分裂指数降低。无反应者有丝分裂活性增加或无变化，凋亡活性降低或无变化。这些发现表明，对短期细胞抑制治疗的凋亡和有丝分裂反应可能是直肠腺癌的额外预测因素。
