Sacks D B
Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Vasc Med. 1999;4(4):253-6. doi: 10.1177/1358836X9900400408.
Despite advances in diagnosis and management, ischemic heart disease remains the leading cause of death in the USA. Serum cardiac enzymes, one of the three fundamental criteria for establishing the diagnosis of myocardial infarction, are not specific for cardiac muscle and have a narrow time-window. The recent development of monoclonal antibodies to cardiac troponin I and troponin T has resulted in cardiac-specific assays. Several published studies have documented the utility of troponin proteins in the evaluation of myocardial necrosis. A brief overview of the characteristics and clinical utility of troponin T and I is presented here.
尽管在诊断和治疗方面取得了进展，但缺血性心脏病仍然是美国的主要死因。血清心肌酶是确立心肌梗死诊断的三项基本标准之一，对心肌不具有特异性，且时间窗较窄。针对心肌肌钙蛋白I和肌钙蛋白T的单克隆抗体的最新研发成果带来了心肌特异性检测方法。多项已发表的研究记录了肌钙蛋白在评估心肌坏死中的作用。本文简要概述了肌钙蛋白T和I的特性及临床应用。
