人类肿瘤中RET激活的分子机制。 - Suppr

Molecular mechanisms of RET activation in human neoplasia.

作者信息

Santoro M, Carlomagno F, Melillo R M, Billaud M, Vecchio G, Fusco A

机构信息

Centro di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia, Università di Napoli Federico II, Naples, Italy.

出版信息

J Endocrinol Invest. 1999 Nov;22(10):811-9. doi: 10.1007/BF03343650.

DOI:10.1007/BF03343650

PMID:10614534

Abstract

摘要

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Molecular mechanisms of RET activation in human neoplasia.人类肿瘤中RET激活的分子机制。

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Mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2.

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[Identification and screening of a family with type 2A multiple endocrine neoplasia with DNA analysis].

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Germ line mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2A and type 2B.日本2A型和2B型多发性内分泌腺瘤患者中ret原癌基因的种系突变。

Jpn J Cancer Res. 1994 Sep;85(9):879-82. doi: 10.1111/j.1349-7006.1994.tb02962.x.

High prevalence of the C634Y mutation in the RET proto-oncogene in MEN 2A families in Spain.西班牙MEN 2A家系中RET原癌基因C634Y突变的高发生率。

J Med Genet. 1999 Jan;36(1):68-70.

Genetic basis of endocrine disease: multiple endocrine neoplasia type 2.内分泌疾病的遗传基础：2型多发性内分泌腺瘤病

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Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation.表达具有2A型多发性内分泌肿瘤突变的RET原癌基因的转基因小鼠中的组织特异性致癌作用。

Cancer Res. 2000 Sep 15;60(18):5254-60.

Germline RET V804M mutation associated with multiple endocrine neoplasia type 2A.

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A family of multiple endocrine neoplasia type 2A with the RET proto-oncogene mutation in codon 618 (Cys-->Arg).

Jpn J Clin Oncol. 2001 Apr;31(4):157-61. doi: 10.1093/jjco/hye034.

Rudolf-Virchow-Preis 1995. The role of RET proto-oncogene mutation analysis in the diagnosis of multiple endocrine neoplasia type 2 (MEN 2) gene carriers and in the discrimination of sporadic and familial medullary thyroid carcinomas and pheochromocytomas.1995年鲁道夫·魏尔啸奖。RET原癌基因突变分析在2型多发性内分泌腺瘤病（MEN 2）基因携带者诊断以及散发性和家族性甲状腺髓样癌与嗜铬细胞瘤鉴别中的作用

Verh Dtsch Ges Pathol. 1995;79:L-LV.

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ALK and RET Inhibitors Promote HLA Class I Antigen Presentation and Unmask New Antigens within the Tumor Immunopeptidome.ALK 和 RET 抑制剂促进 HLA Ⅰ类抗原呈递，并在肿瘤免疫肽组中揭示新抗原。

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Rare Tumors. 2016 Dec 20;8(4):6537. doi: 10.4081/rt.2016.6537. eCollection 2016 Nov 17.

Lenvatinib and other tyrosine kinase inhibitors for the treatment of radioiodine refractory, advanced, and progressive thyroid cancer.乐伐替尼及其他酪氨酸激酶抑制剂用于治疗放射性碘难治性、晚期及进展性甲状腺癌。

Onco Targets Ther. 2016 Oct 20;9:6467-6477. doi: 10.2147/OTT.S84625. eCollection 2016.

Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.RET/PTC 诱导的甲状腺乳头状癌细胞内信号转导及肿瘤微环境的改变。

Front Endocrinol (Lausanne). 2012 May 22;3:67. doi: 10.3389/fendo.2012.00067. eCollection 2012.

In search of tumor suppressing functions of menin.探索Menin的肿瘤抑制功能。

Mol Cell Endocrinol. 2007 Feb;265-266:34-41. doi: 10.1016/j.mce.2006.12.032. Epub 2007 Jan 11.

RET proto-oncogene mutation in a mixed medullary-follicular thyroid carcinoma.

J Endocrinol Invest. 2001 Jan;24(1):51-5. doi: 10.1007/BF03343809.

RET proto-oncogene mutations in thyroid carcinomas: clinical relevance.甲状腺癌中的RET原癌基因突变：临床相关性

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本文引用的文献

Cancer of the thyroid in children: a report of 28 cases.儿童甲状腺癌：28例报告。

J Clin Endocrinol Metab. 1950 Oct;10(10):1296-1308. doi: 10.1210/jcem-10-10-1296.

Ganglioneuromas and renal anomalies are induced by activated RET(MEN2B) in transgenic mice.

Oncogene. 1999 Jan 28;18(4):877-86. doi: 10.1038/sj.onc.1202376.

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.Artemin是胶质细胞源性神经营养因子（GDNF）配体家族的一个新成员，可支持外周和中枢神经元，并通过GFRalpha3-RET受体复合物进行信号传导。

Neuron. 1998 Dec;21(6):1291-302. doi: 10.1016/s0896-6273(00)80649-2.

Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines.影响特定胞外半胱氨酸的MEN 2突变对RET受体的双重作用。

Oncogene. 1998 Dec 3;17(22):2851-61. doi: 10.1038/sj.onc.1202202.

The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.RET/PTC3致癌基因：小鼠甲状腺中的转移性实性乳头状癌

Cancer Res. 1998 Dec 1;58(23):5523-8.

Distinct multiple RET/PTC gene rearrangements in multifocal papillary thyroid neoplasia.多灶性甲状腺乳头状瘤中不同的多种RET/PTC基因重排

J Clin Endocrinol Metab. 1998 Nov;83(11):4116-22. doi: 10.1210/jcem.83.11.5271.

RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.在小鼠甲状腺癌的体细胞多步骤模型中，RET与RB/p53失活协同作用。

Oncogene. 1998 Sep 24;17(12):1625-8. doi: 10.1038/sj.onc.1202381.

GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney.GFRalpha1是发育中的神经系统和肾脏中GDNF的一种重要受体成分。

Neuron. 1998 Jul;21(1):53-62. doi: 10.1016/s0896-6273(00)80514-0.

Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.胶质细胞系源性神经营养因子对与2型多发性内分泌肿瘤综合征及先天性巨结肠相关的ret突变体具有不同的刺激作用。

Endocrinology. 1998 Aug;139(8):3613-9. doi: 10.1210/endo.139.8.6124.

Full activation of MEN2B mutant RET by an additional MEN2A mutation or by ligand GDNF stimulation.通过额外的MEN2A突变或配体GDNF刺激实现MEN2B突变型RET的完全激活。

Oncogene. 1998 May 7;16(18):2295-301. doi: 10.1038/sj.onc.1201759.

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Molecular mechanisms of RET activation in human neoplasia.

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