Brown E S, Khan D A, Nejtek V A
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9101, USA.
Ann Allergy Asthma Immunol. 1999 Dec;83(6 Pt 1):495-503; quiz 503-4. doi: 10.1016/S1081-1206(10)62858-X.
Readers will learn the importance of psychiatric symptomatology with corticosteroid drug therapy, especially when combined with other medications.
A brief history of corticosteroid use over the last five decades was complied utilizing MEDLINE and PSYCHOINFO as sources of information which include peer-reviewed research articles, case studies, and relevant reviews in English.
Corticosteroids are routinely prescribed for a variety of allergic and immunologic illnesses. Psychiatric side effects from corticosteroids include mania, depression and mood disturbances. Psychiatric symptoms usually occur within the first two weeks of corticosteroid therapy and seem to be dose related. Treatment with lithium or antipsychotics may be helpful. Physicians should carefully monitor patients for psychiatric and cognitive side effects of corticosteroid use.
读者将了解精神症状学在皮质类固醇药物治疗中的重要性，尤其是在与其他药物联合使用时。
利用MEDLINE和PSYCHOINFO作为信息来源，汇编了过去五十年来皮质类固醇使用的简要历史，其中包括同行评审的研究文章、案例研究和英文相关综述。
皮质类固醇常用于治疗各种过敏性和免疫性疾病。皮质类固醇的精神副作用包括躁狂、抑郁和情绪障碍。精神症状通常在皮质类固醇治疗的前两周内出现，且似乎与剂量有关。使用锂盐或抗精神病药物进行治疗可能会有帮助。医生应仔细监测患者是否出现皮质类固醇使用的精神和认知副作用。
