Sandoz C, Lesca P, Narbonne J F, Carpy A
UMR 5472 CNRS, Université de Bordeaux I, 351 Cours de la Libération, Talence Cedex, 33405, France.
Arch Biochem Biophys. 2000 Jan 1;373(1):275-80. doi: 10.1006/abbi.1999.1515.
Carbaryl belongs to a series of compounds that activate the CYP1A1 gene. This study demonstrates the inability of carbaryl to compete with 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the rat aryl hydrocarbon (dioxin) receptor. Structural and physicochemical properties of this insecticide, in relation to the requirements for binding to the aryl hydrocarbon receptor, are described. The crystal structure was determined experimentally using X-ray diffraction. A conformational search using molecular mechanics was performed by means of a Monte-Carlo-type method and a stochastic dynamics simulation. Lipophilicity calculations, log P, and molecular lipophilicity potential are also presented. Common and discriminating properties of carbaryl and aryl hydrocarbon receptor ligands are discussed.
