Chen Y C, Shiea J, Sunner J
Institute of Toxicology, Tzu Chi College of Medicine and Humanities, Hualien 970, Taiwan.
Rapid Commun Mass Spectrom. 2000;14(2):86-90. doi: 10.1002/(SICI)1097-0231(20000130)14:2<86::AID-RCM839>3.0.CO;2-O.
A rapid technique for the screening of trace compounds in water by combining solid-phase extraction (SPE) with activated carbon surface-assisted laser desorption/ionization (SALDI) time-of-flight mass spectrometry is demonstrated. Activated carbon is used both as the sorbent in SPE and as the solid in the SALDI matrix system. This eliminates the need for an SPE elution process. After the analytes have been adsorbed on the surfaces of the activated carbon during SPE extraction, the activated carbon is directly mixed with the SALDI liquid and mass spectrometric analysis is performed. Trace phenolic compounds in water were used to demonstrate the effectiveness of the method. The detection limit for these compounds is in the ppb to ppt range.
本文展示了一种将固相萃取（SPE）与活性炭表面辅助激光解吸/电离（SALDI）飞行时间质谱相结合的快速筛选水中痕量化合物的技术。活性炭既用作SPE中的吸附剂，又用作SALDI基质系统中的固体。这消除了SPE洗脱过程的需要。在SPE萃取过程中，分析物吸附在活性炭表面后，将活性炭直接与SALDI液体混合并进行质谱分析。以水中的痕量酚类化合物为例证明了该方法的有效性。这些化合物的检测限在ppb到ppt范围内。
