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补骨脂种子对化学致癌作用的抑制

Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds.

作者信息

Latha P G, Panikkar K R

机构信息

Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Kerala, India.

出版信息

J Ethnopharmacol. 1999 Dec 15;68(1-3):295-8. doi: 10.1016/s0378-8741(99)00062-8.

Abstract

Psoralea corylifolia L. (Fabaceae) seeds are extensively used in Ayurvedic medicine. Topical application of 100 mg/kg body weight of the active fraction (AF) of P. corylifolia seeds inhibited the growth and delayed the onset of papilloma formation in mice, initiated with 7,12-dimethyl benz(a) anthracene and promoted using croton oil. The AF at the same dose, when administered orally, inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA)--induced soft tissue fibrosarcomas significantly. The AF has been shown by gas chromatography analysis to be composed of a mixture of glycerides of fatty acids.

摘要

补骨脂(豆科)种子在阿育吠陀医学中被广泛使用。以100毫克/千克体重的补骨脂种子活性成分(AF)局部涂抹,可抑制由7,12-二甲基苯并(a)蒽引发并用巴豆油促进的小鼠乳头瘤形成,抑制其生长并延迟发病。相同剂量的AF口服时,可显著抑制皮下注射20-甲基胆蒽(MCA)诱导的软组织纤维肉瘤生长。气相色谱分析表明,AF由脂肪酸甘油酯混合物组成。

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