Tokuda H, Nishino H, Shirahashi H, Murakami N, Nagatsu A, Sakakibara J
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Cancer Lett. 1996 Jun 24;104(1):91-5. doi: 10.1016/0304-3835(96)04237-1.
To search for possible antitumor-promoters, two digalactosyl diacylglycerols (DGDGs), which were obtained from the freshwater cyanobacterium Phormidium tenue and possessed a single pair of acyl residues, were evaluated for their inhibitory effects on the two-stage carcinogenesis test in mouse skin. Papillomas in mouse skin were initiated with 390 nmol of 7,12-O-dimethylbenz[a]anthracene and 1 week later, were promoted twice a week with 1.7 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA). Two DGDGs effectively inhibited tumor formation in the sensitive mouse stock even when these compounds were given 1 h before TPA treatment.
为了寻找可能的抗肿瘤促进剂，对从淡水蓝藻纤细席藻中获得的两种双半乳糖基二酰基甘油（DGDG）进行了评估，这两种DGDG具有一对酰基残基，研究了它们对小鼠皮肤两阶段致癌试验的抑制作用。用390 nmol的7,12-O-二甲基苯并[a]蒽引发小鼠皮肤乳头状瘤，1周后，每周用1.7 nmol的12-O-十四酰佛波醇-13-乙酸酯（TPA）进行两次促癌处理。即使在TPA处理前1小时给予这两种DGDG，它们也能有效抑制敏感小鼠品系中的肿瘤形成。
