[硫酸软骨素局部治疗慢性静脉功能不全患者腿部溃疡的有效性]
[Effectiveness of mesoglycan topical treatment of leg ulcers in subjects with chronic venous insufficiency].
作者信息
La Marca G, Pumilia G, Martino A
机构信息
Unità Operativa di Chirurgia Vascolare, Azienda Ospedaliera Civico Fatebenefratelli M. Ascoli, G. di Cristina, Palermo.
出版信息
Minerva Cardioangiol. 1999 Sep;47(9):315-9.
BACKGROUND
Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency.
METHODS
Forty patients, observed in our outpatients department, with venous leg ulcers have been randomized in two groups of twenty subjects, each treated with topical application of mesoglycan (1 or 2 vials/day) or vegetal stimulins and followed for two months, with controls after 15, 30 and 60 days.
RESULTS
At the end of the observation period, ulcer healing rate was 95% in the mesoglycan group, while a lower healing rate was obtained in the stimulins group (80%).
CONCLUSIONS
The present study confirms previous clinical experiences with mesoglycan and suggests its application in the topical treatment of venous ulcers.
背景
本比较临床研究的目的是证明纤溶酶原激活剂硫酸皮肤素局部应用于治疗慢性静脉功能不全患者腿部溃疡的疗效。
方法
在我们门诊观察的40例腿部静脉溃疡患者被随机分为两组，每组20名受试者，分别接受硫酸皮肤素局部应用（每天1或2瓶）或植物刺激素治疗，并随访两个月，在第15、30和60天进行对照检查。
结果
观察期结束时，硫酸皮肤素组溃疡愈合率为95%，而刺激素组愈合率较低（80%）。
结论
本研究证实了之前关于硫酸皮肤素的临床经验，并建议将其应用于静脉溃疡的局部治疗。
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