Hardie J M, Bowden G H
J Dent Res. 1976 Apr;55 Spec No:C50-8. doi: 10.1177/002203457605500325011.
From the preliminary observations described in this report, the following conclusions may be drawn. When attempting to produce diagnostic antiserums specific for S mutans, S mitior, or S sanguis, care must be taken to eliminate cross-reactions as a result of antibodies against extracellular glucans or dextrans. Other antigenic components, associated with the cell wall, may be common to different species. One soluble protein or polypeptide antigen normally present in S sanguis and S mitior may also be demonstrated in certain strains of S mutans. Antiserums prepared against S sanguis, S mitior, or S mutans should be carefully checked for interspecies cross-reactions before being used for identification purposes.
根据本报告中所描述的初步观察结果，可以得出以下结论。在试图制备针对变形链球菌、轻链球菌或血链球菌的诊断抗血清时，必须注意消除因针对细胞外葡聚糖或右旋糖酐的抗体而导致的交叉反应。与细胞壁相关的其他抗原成分可能在不同物种中是共有的。一种通常存在于血链球菌和轻链球菌中的可溶性蛋白质或多肽抗原，在某些变形链球菌菌株中也可能被检测到。针对血链球菌、轻链球菌或变形链球菌制备的抗血清在用于鉴定目的之前，应仔细检查种间交叉反应。
