Latha B, Ramakrishnan M, Jayaraman V, Babu M
Department of Biotechnology, Central Leather Research Institute, Adyar, India.
Comp Biochem Physiol B Biochem Mol Biol. 1999 Nov;124(3):241-9. doi: 10.1016/s0305-0491(99)00101-7.
Wound healing is a finely controlled biological process involving a series of complex cellular interactions. Following inflammation, the wound bed matrix is gradually replaced by granulation tissue followed by the long slow process where collagen accumulates and restores tensile strength. The studies revealed that human granulation tissue varied in many aspects in comparison with normal skin. In granulation tissue the molecular organization of collagen showed an increased amount of type III collagen resembling embryonic tissue. The presence of type V collagen with three distinct chains was the characteristic feature of granulation tissue. The physicochemical properties of collagen extracted from granulation tissue showed the influence of proteoglycans during collagen aggregation and these proteoglycans from the major non-collagenous proteins during the proliferative phase of healing.
伤口愈合是一个精细调控的生物学过程，涉及一系列复杂的细胞相互作用。炎症发生后，伤口床基质逐渐被肉芽组织取代，随后是漫长缓慢的过程，在此过程中胶原蛋白积累并恢复抗张强度。研究表明，与正常皮肤相比，人类肉芽组织在许多方面存在差异。在肉芽组织中，胶原蛋白的分子结构显示III型胶原蛋白的含量增加，类似于胚胎组织。具有三条不同链的V型胶原蛋白的存在是肉芽组织的特征。从肉芽组织中提取的胶原蛋白的物理化学性质显示，蛋白聚糖在胶原蛋白聚集过程中发挥了作用，并且这些蛋白聚糖来自愈合增殖期的主要非胶原蛋白。
