Groell R, Peichel K H, Uggowitzer M M, Schmid F, Hartwagner K
Department of Radiology, University Hospital Graz, Austria.
Eur J Radiol. 1999 Dec;32(3):192-6. doi: 10.1016/s0720-048x(99)00032-7.
To evaluate the potential of spiral computed tomography (CT) densitometry of the lung to assess segmental perfusion defects in patients with acute pulmonary embolism.
Ten patients with known segmental or lobar perfusion defects on ventilation/perfusion scintigraphy and with normal findings in the contralateral lung segment underwent spiral CT of the thorax before and after the administration of contrast material. Regions of interest were defined in 14 segments with normal perfusion and in 14 segments with reduced perfusion. Three consecutive densitometry measurements were performed in each segment.
Those segments with reduced perfusion showed a significantly lower mean CT value on the enhanced scans (-813.4 +/- 57.1 Hounsfield units (HU) vs -794.0 +/- 44.8 HU, P = 0.01) and a significantly decreased contrast enhancement (12.3 +/- 18.2 HU vs 29.8 +/- 16.6 HU, P <0.01) when compared to segments with normal perfusion. Measurements from the unenhanced CT scans were not statistically different between segments with reduced and normal perfusion.
Spiral CT densitometry allows the assessment of at least segmental perfusion defects in patients with acute pulmonary embolism.
评估螺旋计算机断层扫描（CT）肺密度测定法评估急性肺栓塞患者节段性灌注缺损的潜力。
10例通气/灌注闪烁扫描显示已知节段性或叶性灌注缺损且对侧肺段检查结果正常的患者，在注射造影剂前后接受胸部螺旋CT检查。在14个灌注正常的节段和14个灌注减少的节段中定义感兴趣区。每个节段进行连续3次密度测定。
与灌注正常的节段相比，灌注减少的节段在增强扫描上平均CT值显著降低（-813.4±57.1亨氏单位（HU）对-794.0±44.8 HU，P = 0.01），且对比增强显著降低（12.3±18.2 HU对29.8±16.6 HU，P<0.01）。未增强CT扫描的测量结果在灌注减少和正常的节段之间无统计学差异。
螺旋CT密度测定法能够评估急性肺栓塞患者至少节段性的灌注缺损。
