Moriel P, Okawabata F S, Abdalla D S
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brazil.
IUBMB Life. 1999 Oct;48(4):413-7. doi: 10.1080/713803534.
Oxidized lipoproteins and antioxidants were detected during the course of hypercholesterolemia development in cholesterol-fed rabbits. Lipid peroxides in blood plasma and very-low-, low-, and high-density lipoproteins (beta-VLDL, LDL, and HDL) were increased during the course of hypercholesterolemia. The content of phospholipid peroxides increased in beta-VLDL and LDL in parallel to that of cholesterol, whereas the amount of alpha-tocopherol was decreased either in lipoproteins or blood plasma. Ascorbate and urate concentrations were also decreased. Lipid peroxides were positively correlated with volume and area of atherosclerotic lesions, suggesting a relation between the concentrations of lipid peroxides in blood plasma and the progression of atheromatous lesions.
在给胆固醇喂养的兔子高胆固醇血症发展过程中检测到氧化脂蛋白和抗氧化剂。在高胆固醇血症过程中，血浆以及极低密度脂蛋白、低密度脂蛋白和高密度脂蛋白（β-极低密度脂蛋白、低密度脂蛋白和高密度脂蛋白）中的脂质过氧化物增加。β-极低密度脂蛋白和低密度脂蛋白中磷脂过氧化物的含量与胆固醇含量平行增加，而脂蛋白或血浆中的α-生育酚含量降低。抗坏血酸盐和尿酸盐浓度也降低。脂质过氧化物与动脉粥样硬化病变的体积和面积呈正相关，表明血浆中脂质过氧化物浓度与动脉粥样病变进展之间存在关联。
