Girdano J, Zinner M, Hobson R W, Gervin A
Surgery. 1976 Nov;80(5):617-23.
Microaggregates have been implicated as a contributory cause of respiratory distress syndrome. Blood flow and resistance changes are compared between the right and left lungs following the selective administration of stored autologous heparinized blood into the left pulmonary artery. Eight dogs were bled 1,160 +/- 47 c.c. over 3 days. Following storage for 5 days the volume, number and size of microaggregates were measured by multichannel particle size analyzer and compared to 14-day-old human blood. Distribution of blood flow and resistance were calculated from data derived from injection of radioactively tagged microspheres into the right atrium and determination of cardiac output and pulmonary artery and wedge pressures. These measurements were made during a control period, following resuscitation from a 2 hour hemorrhagic shock period with the stored blood and 3 hours after resuscitation. Despite the administration of stored blood with massive amounts of microaggregates into the left pulmonary artery, the distribution of blood flow immediately and 3 hours following resuscitation was the same as in the control period. The pulmonary vascular resistance increased across both lungs but the increase was the same on the left as the right. These data suggest that microaggregates may not be important in the development of the respiratory distress syndrome.
微聚体被认为是呼吸窘迫综合征的一个促成因素。在将储存的自体肝素化血液选择性注入左肺动脉后，比较左右肺的血流和阻力变化。8只狗在3天内失血1160±47立方厘米。储存5天后，用多通道粒度分析仪测量微聚体的体积、数量和大小，并与14天龄的人血进行比较。血流和阻力分布是根据将放射性标记微球注入右心房的数据以及心输出量、肺动脉压和楔压的测定结果计算得出的。这些测量在对照期、用储存血液从2小时失血性休克期复苏后以及复苏后3小时进行。尽管将含有大量微聚体的储存血液注入左肺动脉，但复苏后即刻和3小时的血流分布与对照期相同。两肺的肺血管阻力均增加，但左肺和右肺的增加幅度相同。这些数据表明微聚体在呼吸窘迫综合征的发生中可能并不重要。
