Golovko S I, Zefirov S Iu, Golovko A I, Shpilenia L S, Nekrasov Iu A, Romanenko O I
North-west Regional Medical Centre Bekhterev, Saint Petersburg, Russia.
Vopr Med Khim. 1999 Sep-Oct;45(5):368-74.
A growing bulk of experimental data indicates that change of certain neurotransmitter receptors and voltage-dependent ion cannels are characteristic manifestations accompanying ethanol consumption. A likely target for ethanol effects is the glutamate receptors. Glutamate is one of major excitatory neurotransmitter in the mammalian brain. While the acute application of ethanol inhibits glutamate-induced cationic currents, chronic treatment with ethanol leads to an up-regulation of glutamate receptors.
越来越多的实验数据表明，某些神经递质受体和电压依赖性离子通道的变化是伴随乙醇摄入的特征性表现。乙醇作用的一个可能靶点是谷氨酸受体。谷氨酸是哺乳动物脑中主要的兴奋性神经递质之一。虽然急性给予乙醇会抑制谷氨酸诱导的阳离子电流，但慢性乙醇处理会导致谷氨酸受体上调。
