Watt AP, Morrison I, Evans DC
Department of Medicinal Chemistry (Drug Metabolism Section), Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR UK.
Drug Discov Today. 2000 Jan;5(1):17-24. doi: 10.1016/s1359-6446(99)01434-8.
With pressure on pharmaceutical companies to reduce time-to-market and improve the success rate of new drug candidates, higher-throughput pharmacokinetic (HTPK) support has become an integral part of many drug discovery programmes. This report details the amalgamation of robotics, new sample preparation technologies and highly sensitive and selective mass spectrometric detection systems to deliver the promise of HTPK. A historical perspective on automated bioanalysis with the current approaches and future prospects for the discipline are described.
随着制药公司面临缩短上市时间和提高新药候选物成功率的压力，高通量药代动力学（HTPK）支持已成为许多药物发现计划的一个组成部分。本报告详细介绍了机器人技术、新的样品制备技术以及高灵敏度和选择性的质谱检测系统的融合，以实现HTPK的前景。文中描述了自动生物分析的历史视角、当前方法以及该学科的未来前景。
