氢氯噻嗪对绝经后女性肾脏钙和镁处理的急性影响。

Acute effect of hydrochlorothiazide on renal calcium and magnesium handling in postmenopausal women.

作者信息

Stefíková K, Spustová V, Dzúrik R

机构信息

Department of Pharmacotherapy, Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.

出版信息

Physiol Res. 1999;48(4):327-30.

PMID:10638687

Abstract

A single 50 mg dose of hydrochlorothiazide (HCTZ) decreases the urinary excretion of calcium (U(Ca)V), clearance (C(Ca)) and fractional excretion (FE(Ca)) of calcium. This is accompanied by an increase of total calcium and ionized calcium (Ca2+) concentrations in the serum. On the other hand, HCTZ increases fractional excretion of magnesium (FE(Mg)) and decreases serum Mg2+ concentrations. Moreover, HCTZ decreases markedly clearance of phosphate (C(Pi)) and fractional excretion of phosphate (FE(Pi)) and increases serum phosphate (Pi) concentrations in healthy postmenopausal women. It is concluded that intrinsic renal cellular control promptly uncouples calcium and magnesium tubular reabsorption even without K+ depletion.

摘要

单次服用50毫克氢氯噻嗪（HCTZ）可降低尿钙排泄量（U(Ca)V）、钙清除率（C(Ca)）和钙分数排泄率（FE(Ca)）。与此同时，血清总钙和离子钙（Ca2+）浓度会升高。另一方面，HCTZ会增加镁的分数排泄率（FE(Mg)）并降低血清Mg2+浓度。此外，在健康的绝经后女性中，HCTZ会显著降低磷酸盐清除率（C(Pi)）和磷酸盐分数排泄率（FE(Pi)），并提高血清磷酸盐（Pi）浓度。得出的结论是，即使在没有钾缺乏的情况下，肾脏细胞的内在调控也会迅速解除钙和镁的肾小管重吸收之间的耦合。