• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

9-(β-L-阿拉伯呋喃糖基)腺嘌呤的合成及生物学评价

Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.

作者信息

Boudou V, Imbach J L, Gosselin G

机构信息

Laboratoire de Chimie Bioorganique, UMR C.N.R.S. 5625, Université de Montpellier II, Sciences et Techniques du Languedoc, France.

出版信息

Nucleosides Nucleotides. 1999 Nov-Dec;18(11-12):2463-73. doi: 10.1080/07328319908044620.

DOI:10.1080/07328319908044620
PMID:10639749
Abstract

For the first time, the stereospecific synthesis of 9-(beta-L-arabinofuranosyl) adenine was carried out. Unfortunately, and unlike its "natural" D-counterpart Vidarabine, this L-enantiomer did not show significant activity when evaluated against a broad range of viruses.

摘要

首次实现了9-(β-L-阿拉伯呋喃糖基)腺嘌呤的立体选择性合成。遗憾的是，与它的“天然”D型对应物阿糖腺苷不同，这种L型对映体在针对多种病毒进行评估时并未显示出显著活性。

相似文献

1
Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.9-(β-L-阿拉伯呋喃糖基)腺嘌呤的合成及生物学评价
Nucleosides Nucleotides. 1999 Nov-Dec;18(11-12):2463-73. doi: 10.1080/07328319908044620.
2
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.9-[2-(膦酰甲氧基)乙基]腺嘌呤和(R)-9-[2-(膦酰甲氧基)丙基]腺嘌呤新型α-硼烷核苷酸类似物的合成、体外抗病毒评估及稳定性研究
J Med Chem. 2006 Dec 28;49(26):7799-806. doi: 10.1021/jm060030y.
3
Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.HIV及其他病毒的聚阴离子抑制剂。7. 源自环糊精的聚阴离子化合物和聚两性离子化合物作为HIV传播抑制剂
J Med Chem. 1998 Dec 3;41(25):4927-32. doi: 10.1021/jm970661f.
4
Synthesis and antiviral evaluation of unnatural beta-L-enantiomers of 3'-fluoro- and 3'-azido-2',3'-dideoxyguanosine derivatives.3'-氟-和3'-叠氮基-2',3'-二脱氧鸟苷衍生物的非天然β-L-对映体的合成及抗病毒评价
Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):205-17. doi: 10.1080/15257770008033004.
5
Antiviral activity spectrum of phenoxazine nucleoside derivatives.苯并嗪核苷衍生物的抗病毒活性谱。
Antiviral Res. 2019 Mar;163:117-124. doi: 10.1016/j.antiviral.2019.01.010. Epub 2019 Jan 23.
6
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.环状1-(S)-[3-羟基-2-(膦酰甲氧基)丙基]-5-氮杂胞嘧啶的酯类前药：合成与抗病毒活性
J Med Chem. 2007 Nov 15;50(23):5765-72. doi: 10.1021/jm0707166. Epub 2007 Oct 19.
7
Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.新型核苷和核苷酸类似物作为抗DNA病毒和/或逆转录病毒药物的设计、合成及生物学评价
J Med Chem. 2001 Oct 25;44(22):3710-20. doi: 10.1021/jm010216r.
8
Synthesis and antiviral evaluation of 4'-alkoxy analogues of 9-(beta-D-xylofuranosyl)adenine.9-(β-D-木糖呋喃糖基)腺嘌呤的4'-烷氧基类似物的合成及抗病毒评价
Antivir Chem Chemother. 2009;19(5):201-12. doi: 10.1177/095632020901900503.
9
Polyanion inhibitors of human immunodeficiency virus and other viruses. 5. Telomerized anionic surfactants derived from amino acids.人类免疫缺陷病毒及其他病毒的聚阴离子抑制剂。5. 源自氨基酸的端粒化阴离子表面活性剂。
J Med Chem. 1997 Jan 31;40(3):342-9. doi: 10.1021/jm960493b.
10
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.（S）-9-[3-羟基-2-（膦酰甲氧基）丙基]腺嘌呤的烷氧基烷基酯是野生型和耐药型人类免疫缺陷病毒1型体外复制的有效抑制剂。
Antimicrob Agents Chemother. 2006 Aug;50(8):2857-9. doi: 10.1128/AAC.01223-05.