Connolly S B, Lewis E J, Lindholm J S, Zelickson B D, Zachary C B, Tope W D
Department of Dermatology, University of Minnesota, Minneapolis, USA.
J Am Acad Dermatol. 2000 Feb;42(2 Pt 2):343-7. doi: 10.1016/s0190-9622(00)90108-7.
Verruciform xanthoma is an uncommon mucocutaneous condition of uncertain cause that only occasionally affects the skin. The histopathology is distinctive for the presence of foamy histiocytes present within elongated dermal papillae. Although simple excision of intraoral lesions is reportedly curative, treatment of cutaneous lesions has not been previously reported. We describe a 62-year-old man with a large lesion of verruciform xanthoma affecting both inguinal folds. Immunohistochemical staining, reverse transcriptase polymerase chain reaction for human papilloma virus, and ultrastructural analysis were performed to investigate the pathogenesis of this lesion. The results of these studies support the theory that the source of lipid in dermal histiocytes is degenerating keratinocytes. Initial treatment with wire loop electrosection, pulsed dye (585 nm) laser, and x-ray therapy of this patient proved unsuccessful. Preliminary success has been achieved using wide surgical excision with primary closure.
疣状黄色瘤是一种病因不明的罕见黏膜皮肤疾病，仅偶尔累及皮肤。其组织病理学特征为在细长的真皮乳头内存在泡沫状组织细胞。虽然据报道，口腔内病变的单纯切除可治愈，但此前尚未有关于皮肤病变治疗的报道。我们描述了一名62岁男性，双侧腹股沟皱襞处有一个巨大的疣状黄色瘤病变。进行了免疫组织化学染色、人乳头瘤病毒逆转录聚合酶链反应及超微结构分析，以研究该病变的发病机制。这些研究结果支持真皮组织细胞中脂质来源是退变角质形成细胞的理论。该患者最初采用钢丝圈电切术、脉冲染料（585nm）激光及X线治疗均未成功。采用广泛手术切除并一期缝合已取得初步成功。
