关于β-肾上腺素能对人体胃酸和胃泌素对低血糖反应的影响
On the beta-adrenergic contribution to the gastric acid and gastrin responses to hypoglycaemia in man.
作者信息
Christensen K C, Stadil F
出版信息
Scand J Gastroenterol Suppl. 1976;37:81-6.
To study the beta-adrenergic contribution to the hypoglycaemic stimulation of gastric acid and gastrin release the effect of an equal and extensive beta-adrenergic blockade with three drugs was studied. Propranolol was investigated in 12, pindolol in 22, and practolol in 11 patients. Fasting concentration of gastrin serum and spontaneous acid secretion were not reduced by the drugs. Propranolol eliminated the gastrin response to hypoglycaemia, pindolol reduced it, and practolol caused no alteration. The hypoglycaemic acid response was reduced by all three drugs, propranolol reduced the response to one-half and was the strongest inhibitor, practolol the weakest. It is concluded that beta-adrenergic receptors may be of major importance for the hypoglycaemic stimulation of the stomach, but the receptors respond differently from the receptors in the heart.
为研究β-肾上腺素能对低血糖刺激胃酸和胃泌素释放的作用，我们研究了三种药物同等程度且广泛的β-肾上腺素能阻断效应。对12例患者使用普萘洛尔进行研究，22例使用吲哚洛尔，11例使用醋氨心安。药物并未降低空腹时胃泌素血清浓度和自发胃酸分泌。普萘洛尔消除了低血糖对胃泌素的反应，吲哚洛尔使其减弱，而醋氨心安则未引起改变。三种药物均降低了低血糖引起的胃酸反应，普萘洛尔将反应降低至一半，是最强的抑制剂，醋氨心安最弱。结论是，β-肾上腺素能受体可能对低血糖刺激胃的作用至关重要，但这些受体的反应与心脏中的受体不同。
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