Loh B
Gastroenterol Jpn. 1981;16(3):205-12. doi: 10.1007/BF02815799.
The nature of adrenergic mechanism involved in gastrin release in response to local stimuli and feeding is still unclear. In the present study, the effect of phenoxybenzamine, a potent alpha-blocking agent, on the gastrin release in response to glycine perfusion (pH 7.0) of an isolated canine antral pouch was examined. The experiment was repeated with truncal vagotomy performed before glycine perfusion. It was found that gastrin concentrations measured via right gastroepiploic vein were significantly increased during phenoxybenzamine infusion with and without truncal vagotomy. This finding indicates the presence of an alpha-adrenergic mechanism which inhibits gastrin release when the antrum is locally stimulated. After the drug was discontinued, though there was an enhancement in gastrin response in both saline and glycine perfused groups, the peak gastrin levels were reached earlier in the vagotomized dogs. This finding might indicate the influence of vagus nerve during the experiment.
参与胃泌素释放以响应局部刺激和进食的肾上腺素能机制的本质仍不清楚。在本研究中，研究了强效α-阻滞剂酚苄明对离体犬胃窦袋甘氨酸灌注（pH 7.0）后胃泌素释放的影响。在甘氨酸灌注前进行迷走神经切断术，重复该实验。结果发现，在输注酚苄明期间，无论是否进行迷走神经切断术，通过胃网膜右静脉测得的胃泌素浓度均显著升高。这一发现表明存在一种α-肾上腺素能机制，当胃窦受到局部刺激时，该机制会抑制胃泌素释放。停药后，尽管生理盐水和甘氨酸灌注组的胃泌素反应均增强，但迷走神经切断的犬只胃泌素峰值水平出现得更早。这一发现可能表明实验期间迷走神经的影响。
