Fasching W
Wien Klin Wochenschr Suppl. 1975;32:3-20.
An implantable ventricular-aortic blood pump was employed for the functional replacement of the left heart. Pilot studies were performed in 12 dogs to test new materials and manufacturing innovations used in the production of the blood pumps. Further pilot studies were undertaken to evaluate prophylactic measures against infection along percutaneous driving lines. A skin button made from biomaterials and covered with antibiotics was subcutaneously implanted in 2 dogs and 5 calves. No infection was seen along the percutaneous lines for up to 6 months later. After the implantation technique had been worked out in 15 calves acute haemodynamic studies were undertaken. The implanted pump took over, on average, 88% of the cardiac output. The peak systolic ventricular pressure was decreased from 106 to 18 mm Hg. The myocardial oxygen consumption was thereby decreased by 21% in respect to the control value. A ventricular-aortic blood pump was implanted in 12 calves for long-term studies. The longest duration of pump experimentation was 73 days. The laboratory examinations show that all body functions return to normal within 10 days and that the pumping device is completely integrated into the living organism.
使用可植入式心室-主动脉血泵来功能性替代左心。在12只狗身上进行了初步研究，以测试血泵生产中使用的新材料和制造创新。还进行了进一步的初步研究，以评估针对经皮驱动线感染的预防措施。将由生物材料制成并覆盖抗生素的皮肤纽扣皮下植入2只狗和5头小牛体内。在长达6个月的时间里，经皮线路未出现感染。在15头小牛身上确定植入技术后，进行了急性血流动力学研究。植入的血泵平均承担了88%的心输出量。心室收缩压峰值从106毫米汞柱降至18毫米汞柱。心肌耗氧量相对于对照值降低了21%。在12头小牛身上植入了心室-主动脉血泵进行长期研究。泵实验的最长持续时间为73天。实验室检查表明，所有身体功能在10天内恢复正常，并且泵装置完全融入了生物体。
