Kampmeier J, Schäfer S, Lang G E, Lang G K
Universitäts-Augenklinik Ulm.
Ophthalmologe. 1999 Dec;96(12):805-12. doi: 10.1007/s003470050500.
Examination of morphology in plane corneal ablation (in vitro) induced by an Er:YAG-laser (2.94 microns) in two modes: free-running (50 microseconds) and q-switched (200 ns).
Sequences of different fluences in each mode were applied to freshly enucleated swine eyes. Parameters of free-running mode: fluences 1.21-4.77 J/cm2, frequency 80 Hz, spot size 500 microns FWHM, hexagonal spot shape. Parameters of q-switched mode: fluences 0.79-2.33 J/cm2, frequency 20 Hz, spot size 500 microns FWHM, round spot shape.
Histology showed thermal damage of 10-25 microns in depth caused by the free-running mode compared with 4.5-7.5 microns by the q-switched mode. In both gross photography and scanning electron microscopic examination, the surface was found to be more homogeneous and smoother in the q-switched mode.
Depending on the different application modes, both laser systems could be used for a defined corneal ablation in photorefractive keratectomy. However, at the moment, results using the Er:YAG laser are not as favorable as with the excimer laser.
研究铒钇铝石榴石激光(2.94微米)以两种模式(自由运转模式(50微秒)和调Q模式(200纳秒))进行平面角膜消融(体外)时的形态学变化。
将每种模式下不同能量密度的序列应用于刚摘除的猪眼。自由运转模式参数:能量密度1.21 - 4.77 J/cm²,频率80 Hz,光斑尺寸半高宽500微米,光斑形状为六边形。调Q模式参数:能量密度0.79 - 2.33 J/cm²,频率20 Hz,光斑尺寸半高宽500微米,光斑形状为圆形。
组织学显示,自由运转模式造成的热损伤深度为10 - 25微米,而调Q模式为4.5 - 7.5微米。在大体摄影和扫描电子显微镜检查中,均发现调Q模式下的角膜表面更均匀且更光滑。
根据不同的应用模式,两种激光系统均可用于准分子激光原位角膜磨镶术中特定的角膜消融。然而,目前铒钇铝石榴石激光的效果不如准分子激光。