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[产前应激对雄性水田鼠(Arvicola terrestris)下丘脑-垂体-肾上腺系统活性及脂肪代谢的影响]

[Effect of prenatal stress on the hypothalamo-hypophyseal-adrenal system activity and fat metabolism in the male water vole Arvicola terrestris].

作者信息

Makarova E N, Bazhan N M

机构信息

Institute of Biochemistry of the Russian Acad. Med. Sci., Novosibirsk, Russia.

出版信息

Ross Fiziol Zh Im I M Sechenova. 1999 Aug;85(8):1109-15.

Abstract

The HPA axis function and the fat metabolism were studied in adult male water voles born to intact mothers and mothers deprived of food on the 15th and 18th days of their pregnancy. The HPA response to emotional stress was relatively low in experimental males in winter. The hormonal response to a 24-hrs food deprivation diminished in experimental group only in February. The blood level of free fatty acids was increased in experimental group as compared to the control one. The short maternal food deprivation modified adaptive abilities of their male progeny.

摘要

对完整母亲所生以及在孕期第15天和第18天被剥夺食物的母亲所生的成年雄性水田鼠的下丘脑-垂体-肾上腺(HPA)轴功能和脂肪代谢进行了研究。在冬季,实验雄性水田鼠对情绪应激的HPA反应相对较低。仅在2月份,实验组对24小时食物剥夺的激素反应有所减弱。与对照组相比,实验组的游离脂肪酸血液水平有所升高。母体短期食物剥夺改变了其雄性后代的适应能力。

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