Le Bourgeois J P, Meignan M, Lasser P, Parmentier C, Pene F, Tubiana M
Recent Results Cancer Res. 1978;65:170-80. doi: 10.1007/978-3-642-81249-1_21.
Fifty patients with non-Hodgkin's lymphoma were treated with total abdominal irradiation to a dose of 3000 rad by anterior and posterior fields treated the same day. Fourteen patients developed complications, four with intestinal obstruction due to stenosis and three with total or partial intestinal irradiation damage. These bowel complications were only seen in patients who had previously had a laparotomy. The ways of preventing these complications are discussed. We have studied renal function by means of clinical examination, biologic and radiologic investigations, and scanning in 75 patients who have received splenic irradiation to a dose of 4000 rad. With a mean follow-up time of 36 months, this study has shown that there was no significant change in blood pressure or in biochemical measurements. However, at the 17th month, nephrotomograms demonstrated cortical atrophy of the upper role of the kidney; at the 8th month, low uptake in the irradiated area was seen on 197Hg neohydrine scanning and a decrease in renal plasma flow in the left kidney during dynamic studies with Hippuran.
50例非霍奇金淋巴瘤患者接受全腹照射，前后野同日照射，剂量为3000拉德。14例出现并发症，4例因狭窄导致肠梗阻，3例出现全肠道或部分肠道放射性损伤。这些肠道并发症仅见于既往接受过剖腹手术的患者。讨论了预防这些并发症的方法。我们通过临床检查、生物学和放射学检查以及扫描，对75例接受4000拉德脾区照射的患者的肾功能进行了研究。平均随访时间为36个月，该研究表明血压或生化指标无显著变化。然而，在第17个月，肾断层造影显示肾上极皮质萎缩；在第8个月，197汞新醇扫描显示照射区域摄取降低，在使用马尿酸进行动态研究时，左肾肾血浆流量减少。
