Faro C J, Reidelberger R D, Palmer J M
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha 68178, Nebraska.
Am J Physiol Regul Integr Comp Physiol. 2000 Jan;278(1):R118-24. doi: 10.1152/ajpregu.2000.278.1.R118.
Our aim was to investigate the cause-effect relationship between intestinal inflammation induced by infection with enteric stages of Trichinella spiralis and decreased host food intake. A suppression of food intake in T. spiralis-infected rats occurred within the first 24 h postinfection (PI) and was maximized by day 6 PI. Food intake, cumulated over an 8-day PI period, decreased by 59% compared with uninfected animals. The anti-inflammatory glucocorticoid betamethasone 21-phosphate was orally administered to rats in their drinking water to suppress T. spiralis-induced jejunal inflammation. When treated with a low dose of glucocorticoid (5.2 microg/ml), food intake in infected rats was still significantly reduced, but only by 21% compared with glucocorticoid-treated, uninfected rats. At the highest glucocorticoid dose (10.4 microg/ml) administered, infection-induced reduction in food intake was not different from that of glucocorticoid-treated, uninfected counterparts. The elevation in jejunal myeloperoxidase activity caused by infection was also significantly blunted by oral glucocorticoid treatment. Our results suggest that suppressed host food intake during enteric T. spiralis infection is directly linked to intestinal inflammation.
我们的目的是研究旋毛虫肠道期感染所致肠道炎症与宿主食物摄入量减少之间的因果关系。旋毛虫感染大鼠在感染后（PI）的最初24小时内出现食物摄入量抑制，并在感染后第6天达到最大值。与未感染动物相比，在8天的感染期内累积的食物摄入量减少了59%。通过在大鼠饮用水中口服抗炎糖皮质激素倍他米松21 - 磷酸来抑制旋毛虫诱导的空肠炎症。当用低剂量糖皮质激素（5.2微克/毫升）治疗时，感染大鼠的食物摄入量仍显著降低，但与接受糖皮质激素治疗的未感染大鼠相比仅降低了21%。在给予最高糖皮质激素剂量（10.4微克/毫升）时，感染诱导的食物摄入量减少与接受糖皮质激素治疗的未感染对照组无异。口服糖皮质激素治疗也显著减轻了感染引起的空肠髓过氧化物酶活性升高。我们的结果表明，肠道旋毛虫感染期间宿主食物摄入量的抑制与肠道炎症直接相关。
