Butkiewicz D, Chorazy M
Zakład Biologii Nowotworów, Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach.
Postepy Hig Med Dosw. 1999;53(5):655-73.
Molecular epidemiology of lung cancer analyses relationship between environment and individual susceptibility. Studying biomarkers of risk at the molecular level allows better understanding of chemical carcinogenesis processes and makes possible early detection of the disease as well as helps its prevention. Risk biomarkers include genetic polymorphism of CYP, GST and NAT genes that participate in metabolic biotransformation of various endo- and exogenous compounds including carcinogens. Exposure to potentially carcinogenic environmental factors plays an important role in etiology of lung cancer, which remains a leading cause of cancer death worldwide. This review presents current knowledge about molecular basis and impact of individual variations in carcinogen metabolism on lung cancer risk.
肺癌分子流行病学分析环境与个体易感性之间的关系。在分子水平上研究风险生物标志物有助于更好地理解化学致癌过程，实现疾病的早期检测并有助于预防。风险生物标志物包括参与各种内源性和外源性化合物（包括致癌物）代谢生物转化的CYP、GST和NAT基因的遗传多态性。接触潜在致癌环境因素在肺癌病因中起重要作用，肺癌仍是全球癌症死亡的主要原因。本综述介绍了关于致癌物代谢个体差异的分子基础及其对肺癌风险影响的现有知识。
