Wiejak J, Wyroba E
Zakład Biologii Komórki, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN w Warszawie.
Postepy Hig Med Dosw. 1999;53(5):705-15.
Structure and essential motifs of beta 3-adrenergic receptor (known previously as atypical beta-AR), which plays a central role in regulation of lipid metabolism have been described. Obesity results from an imbalance between caloric intake and energy expenditure. The consequence of catecholamine activation of beta 3-AR is increased mobilization of fatty acids from triglyceride stores (lipolysis) in brown and white adipose tissue as well as increased fatty acid beta-oxidation and heat-production via UCP-1 (thermogenesis) in brown adipose tissue. A pharmacokinetic effects of beta 3-agonists and putative involvement of Trp/Arg mutation in beta 3-AR gene in obesity and another metabolic disorders have been discussed.
β3肾上腺素能受体（以前称为非典型β-肾上腺素能受体）在脂质代谢调节中起核心作用，其结构和基本基序已被描述。肥胖是由热量摄入与能量消耗之间的失衡导致的。儿茶酚胺激活β3-肾上腺素能受体的结果是，棕色和白色脂肪组织中甘油三酯储存的脂肪酸动员增加（脂肪分解），以及棕色脂肪组织中通过解偶联蛋白-1的脂肪酸β氧化和产热增加（产热）。已经讨论了β3激动剂的药代动力学效应以及β3-肾上腺素能受体基因中色氨酸/精氨酸突变在肥胖和其他代谢紊乱中的可能作用。
