Beagley K W, Wu Z L, Pomering M, Jones R C
Discipline of Pathology, Faculty of Medicine and Health Sciences, University of Newcastle, Callaghan, NSW, Australia.
J Reprod Fertil Suppl. 1998;53:235-45.
In recent years the need to develop vaccines against a variety of sexually transmitted diseases, the desire to treat male infertility and interest in developing alternative contraceptive methods have focused research interest on the immunology of the male reproductive tract. This paper reviews the current state of knowledge of immunity in the male tract. Both physical and immune mechanisms that operate to maintain the blood-testis barrier are discussed with regard to (i) their importance in preventing autoimmune responses against spermatozoa and (ii) how these can be overcome to induce specific immunity in the testis and efferent ducts. The role of both the systemic and mucosal arms of the humoral immune response are discussed both in terms of immune-mediated infertility and the induction of specific immunity. Finally some novel approaches to elicit immunity in the male reproductive tract are discussed.
近年来，开发针对多种性传播疾病的疫苗的需求、治疗男性不育症的愿望以及开发替代避孕方法的兴趣，都将研究重点聚焦在了男性生殖道的免疫学上。本文综述了目前关于男性生殖道免疫的知识现状。讨论了维持血睾屏障的物理和免疫机制，涉及（i）它们在预防针对精子的自身免疫反应中的重要性，以及（ii）如何克服这些机制以在睾丸和输出小管中诱导特异性免疫。从免疫介导的不育症和特异性免疫的诱导两方面讨论了体液免疫反应的全身和黏膜分支的作用。最后讨论了一些在男性生殖道中引发免疫的新方法。
