Reshetnikov A V, Zhigal'tsev I V, Kolomeĭchuk S N, Kaplun A P, Shvets V I, Zhukova O S, Karmenian A V, Ivanov A V, Ponomarev G V
Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia.
Bioorg Khim. 1999 Oct;25(10):782-90.
A liposome preparation of a porphyrin photosensitizer for photodynamic therapy of tumors (PDT) was obtained. The in vitro efficiency of the photosensitizer was enhanced 2.5-fold through the liposome formulation. The composition and some properties of the new preparation were studied. An algorithm for a complex approach to the prediction of photosensitizer efficiencies by model experiments in vitro was developed. This approach is based on the use of two models: the determination of coefficient of distribution between n-octanol and a phosphate buffer, pH 7.4, and the determination of the cytotoxic effect on the culture of CaOv ovarian adenocarcinoma cells.
获得了一种用于肿瘤光动力疗法（PDT）的卟啉光敏剂脂质体制剂。通过脂质体制剂，光敏剂的体外效率提高了2.5倍。研究了新制剂的组成和一些性质。开发了一种通过体外模型实验对光敏剂效率进行复杂预测的算法。该方法基于两种模型的使用：测定正辛醇与pH 7.4的磷酸盐缓冲液之间的分配系数，以及测定对CaOv卵巢腺癌细胞培养物的细胞毒性作用。
