异丙肾上腺素诱导8日龄大鼠腮腺腺泡细胞细胞周期动力学的变化。

Isoproterenol-induced changes in cell cycle kinetics of parotid gland acinar cells in 8-day-old rats.

作者信息

Klein R M, Harrington D B, Piliero S J

出版信息

J Dent Res. 1976 Jul-Aug;55(4):611-6. doi: 10.1177/00220345760550041101.

DOI:10.1177/00220345760550041101

Abstract

Isoproterenol (IPR) was shown to alter some parameters of the parotid gland acinar cell cycle in 8-year-old rats. Although the deoxyribonucleic acid (DNA) synthetic period (S) was decreased and the pre-DNA synthetic (G1) period was lengthened, there were no differences in the total cycle time. There was an increase in the 3H-thymidine labeling index from 35.7 to 50.8% combined with a decrease in the value of the mitotic index from 2.64 to 2.16% after IPR was administered. The results suggest that noncycling (G0) cells may be involved in the normal differentiation of the parotid gland and that IPR alters the transition of acinar cells between the cycling and noncycling state.

摘要

异丙肾上腺素（IPR）被证明可改变8岁大鼠腮腺腺泡细胞周期的一些参数。尽管脱氧核糖核酸（DNA）合成期（S期）缩短，DNA合成前期（G1期）延长，但总周期时间并无差异。给予IPR后，3H-胸腺嘧啶核苷标记指数从35.7%增至50.8%，同时有丝分裂指数值从2.64%降至2.16%。结果表明，非循环（G0）细胞可能参与腮腺的正常分化，且IPR改变了腺泡细胞在循环和非循环状态之间的转变。