Di Carlo C, Tommaselli G A, Pisano G, Nasti A, Rossi V, Palomba S, Nappi C
Dipartimento di Ginecologia e Ostetricia, Università degli Studi di Napoli Federico II, Naples, Italy.
Menopause. 2000 Jan-Feb;7(1):36-41. doi: 10.1097/00042192-200007010-00007.
To evaluate serum leptin levels in postmenopausal women who are receiving hormone replacement therapy (HRT) and postmenopausal women who are not receiving HRT with similar body mass index (BMI) to determine whether estrogens exert effects on leptin secretion.
Cross-sectional, prospective study comparing serum leptin levels in premenopausal women, postmenopausal women who were not receiving HRT (group A), and postmenopausal women who were receiving HRT (group B).
Serum leptin levels were significantly higher in group A in comparison to group B and control women (15.82 +/- 6.6 ng/ml, 8.14 +/- 4.17 ng/ml, and 10.12 +/- 5.48 ng/ml, respectively; p < 0.05). Total fat mass (FM) was found to be significantly higher in untreated postmenopausal women in comparison to the other two groups (22.66 +/- 2.79 kg vs. 19.14 +/- 3.39 kg vs. 18.98 +/- 3.82 kg; p < 0.05). No significant difference was observed in weight, height, BMI, blood pressure, or glucose levels among the three groups. A linear correlation between BMI and serum leptin levels as well as between total FM and serum leptin levels was observed in all groups. No correlation was found between serum leptin levels and months from menopause and months of HRT.
Our results show that serum leptin is increased in untreated postmenopausal women, possibly as a consequence of the increase in FM, and that HRT reduces serum leptin levels to premenopausal values. These data need further investigation by a broader longitudinal study.
评估接受激素替代疗法（HRT）的绝经后女性和体重指数（BMI）相似但未接受HRT的绝经后女性的血清瘦素水平，以确定雌激素是否对瘦素分泌有影响。
横断面前瞻性研究，比较绝经前女性、未接受HRT的绝经后女性（A组）和接受HRT的绝经后女性（B组）的血清瘦素水平。
与B组和对照组女性相比，A组的血清瘦素水平显著更高（分别为15.82±6.6 ng/ml、8.14±4.17 ng/ml和10.12±5.48 ng/ml；p<0.05）。发现未接受治疗的绝经后女性的总脂肪量（FM）显著高于其他两组（22.66±2.79 kg对19.14±3.39 kg对18.98±3.
