Eph受体酪氨酸激酶及其配体在鸡胚运动神经元和后肢肌肉中的表达。

Expression of Eph receptor tyrosine kinases and their ligands in chick embryonic motor neurons and hindlimb muscles.

作者信息

Iwamasa H, Ohta K, Yamada T, Ushijima K, Terasaki H, Tanaka H

机构信息

Division of Developmental Neurobiology, Kumamoto University Graduate School of Medical Sciences, Honjo, Japan.

出版信息

Dev Growth Differ. 1999 Dec;41(6):685-98. doi: 10.1046/j.1440-169x.1999.00468.x.

DOI:10.1046/j.1440-169x.1999.00468.x

PMID:10646798

Abstract

Evidence is accumulating that Eph receptor tyrosine kinases and their ligands regulate cell migration and axonal guidance during development. It was previously found that one of the Eph receptors, EphA4, is transiently expressed in subsets of chick embryonic motor neurons. Here, the expression of EphA and ephrin-A subfamily members was further examined, and the dynamic patterns of expression in chick embryonic motor neurons found. EphA3, EphA4, ephrin-A2, and ephrin-A5 were also expressed in the connective tissues of limb muscles and EphA3 and EphA4 expressing motor neurons innervated EphA3 and EphA4 expressing limb muscles, respectively. These spatiotemporal expression patterns suggest that EphA and ephrin-A proteins play important roles in muscle patterning and motor axonal guidance.

摘要

越来越多的证据表明，Eph受体酪氨酸激酶及其配体在发育过程中调节细胞迁移和轴突导向。先前发现，Eph受体之一EphA4在鸡胚运动神经元亚群中短暂表达。在此，进一步研究了EphA和ephrin-A亚家族成员的表达，并发现了鸡胚运动神经元中的动态表达模式。EphA3、EphA4、ephrin-A2和ephrin-A5也在肢体肌肉的结缔组织中表达，表达EphA3和EphA4的运动神经元分别支配表达EphA3和EphA4的肢体肌肉。这些时空表达模式表明，EphA和ephrin-A蛋白在肌肉模式形成和运动轴突导向中起重要作用。