Tan J C, Huang C C, Fiel R J
J Med. 1976;7(2):169-76.
The effect on mitosis of a human hematopoietic cell line RPMI-1788 treated with a metal chelate (Zn++) of meso-tetra (p-carboxyphenyl) porphine (Zn-TCPP) alone at various concentrations or in combination with gamma-irradiation at various doses were studied. The results showed that both Zn-TCPP and radiation were effective in interfering with normal mitosis and that the effect of radiation was relatively more effective. Data also suggest interacting effects between Zn-TCPP and gamma-irradiation. At low doses of radiation, Zn-TCPP potentiated the effect of radiation. The reverse seemed to be true at a high dose of radiation. The effects of two porphyrins (Zn-TCPP and hematoporphyrin) and radiation on chromosomes were also studied. Chromosomal aberrations characteristic of radiation were observed. The porphyrins were found not to be effective chromosome-breaking agents under the experimental conditions tested.
研究了用不同浓度的金属螯合物（锌离子）与中-四（对羧基苯基）卟啉（Zn-TCPP）单独处理或与不同剂量的γ射线联合处理人造血细胞系RPMI-1788对有丝分裂的影响。结果表明，Zn-TCPP和辐射均能有效干扰正常有丝分裂，且辐射的效果相对更显著。数据还表明Zn-TCPP与γ射线之间存在相互作用。在低剂量辐射下，Zn-TCPP增强了辐射的效果。在高剂量辐射下情况似乎相反。还研究了两种卟啉（Zn-TCPP和血卟啉）及辐射对染色体的影响。观察到了辐射特有的染色体畸变。在所测试的实验条件下，发现卟啉不是有效的染色体断裂剂。
