Ashina M, Lassen L H, Bendtsen L, Jensen R A, Olesen J
Neurologisk afdeling, Amtssygehuset i Glostrup.
Ugeskr Laeger. 2000 Jan 10;162(2):171-3.
The efficacy of the inhibitor of nitric oxide synthase, NG-monomethyl-L-arginine hydrochloride (L-NMMA), was tested in 16 patients with chronic tension-type chronic headache. The study was designed as a randomized double-blind, crossover trial. Patients were assigned intravenous infusion of 6 mg/kg L-NMMA or placebo on two days separated by at least one week in a randomized order. Headache intensity was measured on a 100 mm visual analogue scale at baseline and at 30 min, 60 min, and 120 min after start of treatment. L-NMMA reduced pain intensity significantly more than placebo: 120 min after start of treatment, the mean pain score was decreased from 49 to 33 with L-NMMA and from 44 to 40 with placebo (p = 0.01). The present study demonstrates that inhibition of NOS has an analgesic effect in chronic tension-type headache.
在16例慢性紧张型头痛患者中测试了一氧化氮合酶抑制剂盐酸NG-单甲基-L-精氨酸（L-NMMA）的疗效。该研究设计为随机双盲交叉试验。患者被随机安排在至少间隔一周的两天内静脉输注6mg/kg的L-NMMA或安慰剂。在基线以及治疗开始后30分钟、60分钟和120分钟，使用100mm视觉模拟量表测量头痛强度。L-NMMA比安慰剂更显著地降低了疼痛强度：治疗开始120分钟后，L-NMMA组的平均疼痛评分从49降至33，安慰剂组从44降至40（p=0.01）。本研究表明，抑制一氧化氮合酶在慢性紧张型头痛中具有镇痛作用。
