周期性呼吸对氧耗量（V(O2)）和二氧化碳排出量（V(CO2)）的影响：基于傅里叶分析的定量方法

Impact of periodic breathing on V(O2) and V(CO2): a quantitative approach by Fourier analysis.

作者信息

Francis D P, Davies L C, Willson K, Piepoli M, Seydnejad S R, Ponikowski P, Coats A J

机构信息

Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, UK.

出版信息

Respir Physiol. 1999 Dec 1;118(2-3):247-55. doi: 10.1016/s0034-5687(99)00074-2.

DOI:10.1016/s0034-5687(99)00074-2

PMID:10647868

Abstract

Oscillations in oxygen uptake (V(O2)) and carbon dioxide production (V(CO2)) in patients with chronic heart failure differ in amplitude and phase from the oscillations in ventilation (periodic breathing, PB), leading some to doubt whether they result from PB. We applied Fourier transforms to a pulmonary gas exchange model to quantify the effects of fluctuations in alveolar ventilation (V(A)). We found that PB causes oscillations in V(O2) and V(CO2), but their amplitude and phase are complex, and vary with workload. At low workloads, the relative oscillations in V(O2) and V(CO2) closely mirror the relative oscillations in V(A). But at high workloads, the metabolic oscillations are attenuated (V(O2) most severely), and the V(O2) peaks precede the ventilatory peaks significantly. This study also explains why normal controls simulating PB at higher workloads fail to reproduce the V(O2) and V(CO2) oscillations seen in spontaneous PB of heart failure.

摘要

慢性心力衰竭患者的摄氧量（V(O2)）和二氧化碳产生量（V(CO2)）的振荡在幅度和相位上与通气振荡（周期性呼吸，PB）不同，这使得一些人怀疑它们是否由PB引起。我们将傅里叶变换应用于肺气体交换模型，以量化肺泡通气量（V(A)）波动的影响。我们发现PB会导致V(O2)和V(CO2)的振荡，但其幅度和相位很复杂，并且会随工作量而变化。在低工作量时，V(O2)和V(CO2)的相对振荡与V(A)的相对振荡密切相关。但在高工作量时，代谢振荡会减弱（V(O2)减弱最严重），并且V(O2)峰值明显先于通气峰值。这项研究还解释了为什么在较高工作量下模拟PB的正常对照无法重现心力衰竭患者自发性PB中出现的V(O2)和V(CO2)振荡。