Valtýsdóttir S T, Gudbjörnsson B, Lindqvist U, Hällgren R, Hetta J
Department of Medical Sciences, University Hospital, Uppsala, Sweden.
J Rheumatol. 2000 Jan;27(1):165-9.
To examine the degree of anxiety and depression and to assess well being and general symptoms in patients with primary Sjögren's syndrome (SS).
A standardized questionnaire, the Hospital Anxiety and Depression Scale, was used to examine the degree of anxiety and depression in patients with primary SS (n = 62) and in age matched healthy female controls. The Gothenburg quality of life instrument (GQOL) was used to assess well being and general symptoms. Patients with rheumatoid arthritis (RA; n = 38) were used as patient controls.
The patients with primary SS had significantly higher scoring rate for "possible" clinical anxiety (48%) and for "possible" clinical depression (32%) compared with reference groups (p<0.05). The physical and mental well being of the patients with primary SS were significantly reduced compared with controls. Furthermore, patients with primary SS complained more commonly of low mood, irritability, headache, gastrointestinal symptoms, and impaired concentration and memory than the patients with RA.
The results indicate that patients with primary SS often have psychiatric symptoms and worse well being, which may affect their quality of life.
研究原发性干燥综合征（SS）患者的焦虑和抑郁程度，并评估其幸福感及一般症状。
采用标准化问卷——医院焦虑抑郁量表，对原发性SS患者（n = 62）及年龄匹配的健康女性对照者的焦虑和抑郁程度进行调查。使用哥德堡生活质量量表（GQOL）评估幸福感及一般症状。类风湿关节炎（RA）患者（n = 38）作为患者对照。
与参照组相比，原发性SS患者“可能存在”临床焦虑的评分率显著更高（48%），“可能存在”临床抑郁的评分率也显著更高（32%）（p<0.05）。与对照组相比，原发性SS患者的身心健康显著降低。此外，与RA患者相比，原发性SS患者更常抱怨情绪低落、易怒、头痛、胃肠道症状以及注意力和记忆力受损。
结果表明，原发性SS患者常出现精神症状且幸福感较差，这可能会影响其生活质量。
