Ohno M, Sugihara J, Miyamura K, Tabata T, Matsuura T, Matsui S, Fukuda H, Ohbayashi C
Department of Surgery, Kakogawa Municipal Hospital, Japan.
Surg Today. 2000;30(1):59-62. doi: 10.1007/PL00010048.
A submucosal tumor of the esophagus was enucleated by a thoracotomy. A microscopic examination showed the tumor to be composed of spindle-shaped cells showing mild nuclear atypia with vague nuclear palisading and scarce mitotic figures. The tumor was surrounded by peripheral lymphoid cuffs. An immunohistochemical study demonstrated diffuse positive staining for S-100 protein in the tumor cells. The lesion was diagnosed to be an esophageal schwannoma based on these pathological features. Benign schwannoma of the esophagus has been described in five cases in four reports in the English literature. This is the sixth case diagnosed by immunohistochemical studies.
通过开胸手术摘除了食管黏膜下肿瘤。显微镜检查显示肿瘤由梭形细胞组成，这些细胞显示出轻度核异型性，核呈模糊的栅栏状排列，有丝分裂象稀少。肿瘤周围有外周淋巴袖套。免疫组织化学研究显示肿瘤细胞中S-100蛋白弥漫性阳性染色。基于这些病理特征，该病变被诊断为食管神经鞘瘤。英文文献中有4篇报道共5例食管良性神经鞘瘤。这是第6例通过免疫组织化学研究确诊的病例。
