Arai T, Sugimura H, Suzuki M, Iwase T, Sakuramachi S, Kimura T, Harada Y, Kino I
Department of Pathology, Hamamatsu University School of Medicine, Japan.
Pathol Int. 1994 Jun;44(6):460-5. doi: 10.1111/j.1440-1827.1994.tb01711.x.
Two cases of benign schwannoma of the esophagus are presented. The tumors were found in the thoracic esophagus of women of 56 and 64 years of age, respectively, who had complained of dysphagia and back pain. Tumorectomies were performed and the tumors were found to be located within the esophageal wall arising from the muscularis propria. The tumors were examined immunohistochemically and ultrastructurally. These tumors were identical in gross, histological and electron microscopic features. Grossly, the tumors showed yellowish-white cut surfaces without hemorrhage or necrosis. Microscopically, they were composed of spindle-shaped cells showing moderate variation in size and shape, and nuclear palisading. Lymphoid aggregates with germinal centers surrounded the tumors. Immunohistochemically, strong reactions for S-100 protein and neuron-specific enolase were observed in the cytoplasm of spindle cells, whereas reactions for muscle actin and desmin were negative. These findings, together with electron microscopic observations, supported the Schwann cell origin of these tumors.
本文报告2例食管良性神经鞘瘤。肿瘤分别位于56岁和64岁女性的胸段食管，患者均有吞咽困难和背痛症状。行肿瘤切除术，发现肿瘤位于食管壁内，起源于固有肌层。对肿瘤进行了免疫组织化学和超微结构检查。这些肿瘤在大体、组织学和电子显微镜特征上均相同。大体上，肿瘤切面呈黄白色，无出血或坏死。显微镜下，肿瘤由梭形细胞组成，细胞大小和形状有中度变异，可见核栅栏状排列。肿瘤周围有含生发中心的淋巴滤泡聚集。免疫组织化学检查显示，梭形细胞胞质内S-100蛋白和神经元特异性烯醇化酶呈强阳性反应，而肌动蛋白和结蛋白呈阴性反应。这些发现以及电子显微镜观察结果均支持这些肿瘤起源于施万细胞。
