成人急性淋巴细胞白血病的治疗结果。

Results of therapy in adult acute lymphocytic leukemia.

作者信息

Einhorn L H, Meyer S, Bond W H, Rohn R J

出版信息

Oncology. 1975;32(5-6):214-20. doi: 10.1159/000225071.

Abstract

27 adult patients with acute lymphocytic leukemia have been analyzed. Complete remission was induced in 9 of 113 patients treated with prednisone +6-MP, 4 of 6 patients treated with prednisone + vincristine, and the one patient treated with a combination of prednisone, vincristine, 6-MP, and methotrexate. The median survival for these 20 patients was 11 months and the median duration of complete remission was 71/2 months. Two of these patients remain in complete remission at 8+ years. Our most recent regimen for remission induction, prednisone + vincristine + daunomycin, has produced complete remission in 7 of 7 patients, with a median duration of complete remission of 15 months. Three patients remain in their original complete remission from 16+ to 24+ months, and 5 of these 7 patients remain alive from 16+ to 24+ months.

摘要

对27例成年急性淋巴细胞白血病患者进行了分析。在接受泼尼松+6-巯基嘌呤治疗的113例患者中，9例实现完全缓解；在接受泼尼松+长春新碱治疗的6例患者中，4例实现完全缓解；在接受泼尼松、长春新碱、6-巯基嘌呤和甲氨蝶呤联合治疗的1例患者中，该患者实现完全缓解。这20例患者的中位生存期为11个月，完全缓解的中位持续时间为7.5个月。其中2例患者在8年多后仍处于完全缓解状态。我们最近用于诱导缓解的方案，即泼尼松+长春新碱+柔红霉素，在7例患者中有7例实现完全缓解，完全缓解的中位持续时间为15个月。3例患者从16个多月到24个多月一直处于最初的完全缓解状态，这7例患者中有5例从16个多月到24个多月仍存活。